With greater prograf whole blood trough concentrations in patients with severe hepatic impairment, there is a greater risk of adverse reactions and dosage reduction is recommended.

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hypertension is a common adverse effect of prograf therapy and may require antihypertensive therapy see adverse reactions 6.

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when interpreting measured concentrations, consider that the time to achieve prograf steady state is approximately 7 days after initiating or changing the prograf dose.

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