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The renagel carbonate studies include one double-blind, active-controlled, cross-over study with two 8-week treatment periods using renagel carbonate tablets n 79 ; one open-label, active-controlled, cross-over study with two 4-week treatment periods using renagel carbonate powder n 31 ; and one randomized, parallel, open-label study using renagel carbonate powder n 144 dosed once daily or renagel hydrochloride tablets n 73 dosed three times daily for 24 weeks.

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5 mg dl following a two-week phosphate-binder washout period, were randomized to receive renagel n 97 or active control n 46 open label for 12 weeks.