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While atazanavir/ritonavir does reduce the lamotrigine plasma concentrationno adjustments to the recommended dose-escalation guidelines for LAMICTAL should be necessary solely based on the use of atazanavir/ritonavirDose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMICTAL based on concomitant AED or other concomitant medicationssee Tables 12and 5In patients already taking maintenance doses of LAMICTAL and not taking glucuronidation inducersthe dose of LAMICTAL may need to be increased if atazanavir/ritonavir is addedor decreased if atazanavir/ritonavir is discontinuedsee CLINICAL PHARMACOLOGY

Overdose symptoms may include blurred visionproblems with coordinationincreased seizuresfeeling light-headedor fainting.

Lamotrigine is an inhibitor of renal tubular secretion via organic cationic transporter 2OCT2proteinssee CLINICAL PHARMACOLOGYThis may result in increased plasma levels of certain drugs that are substantially excreted via this routeCoadministration of LAMICTAL with OCT2 substrates with a narrow therapeutic indexe.gdofetilideis not recommended.

Lamictallamotrigineis an anti-epileptic medicationalso called an anticonvulsant.

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c monoterapia con lamictal dispersable o terapia adjunta en pacientes que toman otros medicamentos que no inhiben ni inducen de manera significativa la glucuronidaci n de lamotrigina ver interacciones medicamentosas y de otro g nero .