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When it first gained FDA approval in 1991Zofran came in the form of an injection for intravenousIVuseOver the yearsthe FDA has approved various oral forms of the drug.

Ondansetron is extensively metabolized in humanswith approximately 5of a radiolabeled dose recovered as the parent compound from the urineThe metabolites are observed in the urineThe primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.

Known to have hypersensitivitye.ganaphylaxisto ondansetron or any of the components of the formulationsee ADVERSE REACTIONSreceiving concomitant apomorphine due to the risk of profound hypotension and loss of consciousness.

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