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Use Zetiaezetimibeas ordered by your doctorRead all information given to youFollow all instructions closely.

No dosage adjustment is necessary in patients with mild hepatic impairmentsee WARNINGS AND PRECAUTIONS

Caution should be exercised when using ZETIA and cyclosporine concomitantly due to increased exposure to both ezetimibe and cyclosporineCyclosporine concentrations should be monitored in patients receiving ZETIA and cyclosporine.

Clinical studies have demonstrated that elevated levels of total-CLDL-C and Apo Bthe major protein constituent of LDLpromote human atherosclerosisIn additiondecreased levels of HDL-C are associated with the development of atherosclerosisEpidemiologic studies have established that cardiovascular morbidity and mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-CLike LDLcholesterol-enriched triglyceride-rich lipoproteinsincluding very-low-density lipoproteinsVLDLintermediate-density lipoproteinsIDLand remnantscan also promote atherosclerosisThe independent effect of raising HDL-C or lowering TG on the risk of coronary and cardiovascular morbidity and mortality has not been determined.

There are no adequate and well-controlled studies of ezetimibe in pregnant womenEzetimibe should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

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